Silk Voice Injectable Implant and Proprietary Catheter Delivery System

When injected, Silk Voice provides immediate volume augmentation to the vocal fold tissue. The porous particles remain at the site of implantation, providing a scaffold for local tissue infiltration. This cellular infiltrated silk scaffold provides the long term restoration and augmentation. Silk particles, combined with a crosslinked hyaluronic acid carrier, enables initial volume restoration which is replaced with new tissue over time. Shown to provide immediate medialization of the vocal fold and projected to last a minimum of 12 months. A slow absorption profile sets silk apart from other biomaterial such as collagen, elastin, and keratin.

Silk Voice Material

Silk protein is a natural, biodegradable material. Regenerated silk protein converted to porous silk microparticles make up Silk Voice’s proprietary formulation with the addition of a crosslinked hyaluronic acid carrier. Silk microparticles have been engineered to match the biomechanics of soft tissues and provide an ideal environment for cellular infiltration, providing a platform for small gauge injectable delivery. Silk Voice is more viscous and cohesive than similar substances, leading to better bulking and less migration within the vocal folds.